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 Shannon Wahl, M.D.
Current Positions:
- Associate Clinical Investigator, BSRI
Contact Information:
270 Masonic Ave.
San Francisco, CA 94118
Phone: (415) 749-6692
Fax: (415) 567-5899
Email: swahl@bloodsystems.org
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Education:
- B. S., Biochemistry, Louisiana State University
- M. D., Louisiana State University Health Sciences Center
Training:
- Internship and Residency, Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA
- Chief Residency, Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA
- Fellowship, Pediatric Hematology/Oncology, Children’s Hospital & Research Center Oakland
- Fellowship, Transfusion Medicine, University of California, San Francisco / Blood Centers of the Pacific, San Francisco, CA
Appointments:
Assistant Clinical Investigator, Blood Systems Research Institute
Assistant Medical Director, Blood Centers of the Pacific
Research Interests:
- Transfusion outcomes in children with hematologic/oncologic disorders
- Alloimmunization in sickle cell anemia
- Impact of erythrocytapheresis in sickle cell anemia
Current research:
Establishing a Brazilian Sickle Cell Disease Cohort and Identifying Molecular Determinants of Response to Transfusions and Genetic Determinants of Alloimmunization
This project will develop a centralized electronic database of clinical, laboratory and transfusion information as well as a biospecimen repository for a cohort of ~7,000 sickle cell patients in Brazil. Planned initial studies from this cohort include characterization of the immune modulation which occur with transfusion and identification of single nucleotide polymorphisms that contribute to the risk of red blood cell alloimmunization in sickle cell anemia.
Gene Expression Profiles in Sickle Cell Disease
In order to characterize gene expression patterns in pediatric sickle cell patients, mRNA expression was quantified for patients at baseline, during crisis and post red blood cell transfusion. Evaluation of differential gene expression patterns in these clinical scenarios may further characterize the central pathways involved in sickle cell pathophysiology as well as those pathways impacted by transfusion therapy.
Alloimmunization of Pediatric Sickle Cell Patients on a Chronic Transfusion Program: Impact of Erythrocytapheresis
The alloimmunization rates of pediatric sickle cell patients on chronic transfusion programs were examined to determine differences in rates of antibody formation between patients on simple and exchange programs
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