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Sheila KeatingSheila Keating, PhD

Current Positions:

  • Staff Scientist II - Immunology Core, BSRI

Contact Information:
270 Masonic Ave.
San Francisco, CA 94118
Phone: (415) 923-5771 x499
Fax: (415) 775-3859
Email: skeating@bloodsystems.org

 

 

 

Download a scientific summary [pdf file]

Download a curriculum vitae [pdf file]

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Education:

  • Weatherall Institute of Molecular Medicine, Open University, Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
    PhD Research Supervisor: Professor Adrian Hill
  • Tulane School of Public Health and Tropical Medicine, New Orleans, LA
    MSPH in Tropical Medicine
  • College of the Holy Cross, Worcester, MA
    BA in Biology

Training/Appointments:

  • Postdoctoral Research Fellow, B cell Memory and Pneumococcal Vaccines, Department of Infectious Diseases and Microbiology, Institute of Child Health, University College London, London, UK
  • Scientist, Malaria Vaccine Program, Centre for Clinical Vaccinology and Tropical Medicine Nuffield Department of Medicine, University of Oxford, Oxford, UK
  • Senior Research Program Coordinator, Core Immunology Laboratory, HIV Prevention Trials Network, Division of Infectious Diseases, Johns Hopkins University, School of Medicine, Baltimore, MD

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Research Interests

  • Development of new assays for the detection of HIV incidence
  • Investigation of immune responses during early infection
  • Study of the maturation of B and T cell responses over time in response to vaccination or infection

Publications

Keating SM, Dodge J, Norris PJ, French A, Glesby M, Edlin B, Latham P, Greenblatt RM and Peters MG. 2013. The effect of hepatic fibrosis and HCV viremia on serum inflammatory mediators in HIV infection -The Women’s Interagency HIV Study. In preparation for JIDS, Submission September 2013.

Keating SM, Heitman JD, Wu S, Deng X, Stramer SL, Kuhns MC, Mullen C, Norris PJ, Busch MP. 2013. Cytokine and Chemokine Responses in the Acute Phase of Hepatitis B Virus Replication in Naïve and Previously Vaccinated Blood and Plasma Donors. JID. Accepted September 2013, in press.

Shikuma C, Barbour J, Ndhlovu L, Keating S, Norris PJ, Budoff M, Parikh N, Seto T, Gangcuangco LM, Ogata-Arakaki D, Chow D. Plasma MCP-1 and TNF-α Levels Predict the Presence of Coronary Artery Calcium in HIV-infected Individuals Independent of Traditional Cardiovascular Risk Factors. AIDS Res Hum Retroviruses. 2013 Aug 28.

Li,S, Ying W, Keating SM, Du H, Sammet CL, Zadikoff C, Mahadevia R, Epstein LG, Ragin AB. 2013. Matrix metalloproteinase levels in early HIV infection and relation to in vivo brain status, Neurovirology.

Fleck S, Bautista G, Keating SM, Lee TH, Keller RL, Moon-Grady AJ, Gonzales K, Norris PJ, Busch MP, Kim C, Romero R, Lee H, Miniati D, Mackenzie TC. 2013. Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia. Pediatric Research.

Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG. 2013. Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient. In press Plos Path.

Alencar C, Sabino E, Carvalho S, Leao S, Carneiro-Proietti A, Capuani L, Oliveira C, Carrick D, Birch R, Gonçalez T, Keating S, Swanson P, Hackett J Jr, Busch M; for the NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component. 2013. HIV genotypes and primary drug resistance among HIV seropositive blood donors in Brazil: role of infected blood donors as sentinel populations for molecular surveillance of HIV. J Acquir Immune Defic Syndr.

Henrich TJ, Hu Z, Li JZ, Sciaranghella G, Busch MP, Keating SM, Gallien S, Lin NH, Giguel FF, Lavoie L, Ho V, Armand P, Sagar M, LaCasce AS, Kuritzkes DR. 2012. Long-Term Reduction in Peripheral Blood HIV-1 Reservoirs Following Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation. In Press, JID.

Batista MD, Tincati C, Milush JM, Ho EL, Ndhlovu LC, York VA, Kallas EG, Kalil J, Keating SM, Norris PJ, Chang D, Unemori P, Leslie KS, Maurer T, Liao W, Nixon DF. 2012. CD57 expression and cytokine production by T cells in lesional and unaffected skin from patients with psoriasis. PLOS One.

Keating SM, Hanson D, Lebedeva M, Laeyendecker O, Ali-Napo NL, Owen SM, Stramer SL, Moore R, Norris PJ, Busch MP. 2012. Less Sensitive and Avidity Modifications of the VITROS® Anti-HIV1+2 Assay for Detection of Recent HIV Infections and Incidence Estimation. Journal of Clinical Microbiology.

Keating SM, Jacobs E, Norris PJ. 2012 Soluble mediators of inflammation in HIV and their implications for therapeutics and vaccine development. Cytokine Growth Factor Rev; 23(4-5):193-206.

Eriksson EM, Milush JM, Ho EL, Batista ME, Holditch SJ, Keh CE, Norris P, Keating SM, Deeks SG, Hunt PW, Martin JN, Rosenberg MG, Hecht FM. 2011. Expansion of CD8+ T cells lacking SEMA4D/CD100 during HIV-1 infection identifies a subset of cells with decreased functional capacity. Blood; 119(3):745-55.

Kassanjee R, Welte A, McWalter TA, Keating SM, Vermeulen M, et al. 2011 Seroconverting Blood Donors as a Resource for Characterising and Optimising Recent Infection Testing Algorithms for Incidence Estimation. PLoS ONE 6(6); e20027.

Keating SM, Golub ET, Nowicki M, Young M, Anastos K, Crystal H, Zhang J, Greenblatt R, Desai S, Wu S, Landay A, Gange S, Norris PJ. and the Women’s Interagency HIV Study. 2011. The effect of HIV infection and HAART on inflammatory biomarkers in a population-based cohort of US women. AIDS; 25(15):1823-32.

Letvin NL, Rao SS, Montefiori DC, Seaman MS, Sun Y, Lim SY, Yeh WW, Asmal M, Gelman RS, Shen L, Whitney JB, Seoighe C, Lacerda M, Keating S, Norris PJ, Hudgens MG, Gilbert PB, Buzby AP, Mach LV, Zhang J, Balachandran H, Shaw GM, Schmidt SD, Todd JP, Dodson A, Mascola JR, Nabel GJ. 2011. Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys. Sci Transl Me,. 4;3(81):81ra36.

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