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Mark SeielstadMark Seielstad, PhD

Current Positions:

  • Associate Investigator, BSRI
  • Associate Professor, Institute for Human Genetics and Department of Laboratory Medicine, University of California, San Francisco
  • Adjunct Investigator, Genome Institute of Singapore

Contact Information:
270 Masonic Avenue
San Francisco, CA 94118
Phone: (415) 354-1372
Fax: (415) 901-0733
Email: Mark.Seielstad@ucsf.edu
Links: http://humgen.medschool.ucsf.edu/faculty/seielstad-mark-phd

Download a scientific summary [pdf file]

Download a curriculum vitae [pdf file]

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Education:

  • B.S., with Honors, Biological Sciences, Stanford University, California
  • A.B., Classical Studies, Stanford University, California
  • Ph.D., Biology, Harvard University, Cambridge, Massachusetts

Research Interests:

  • Identifying human genetic variation altering risk of disease - especially susceptibility to infectious diseases, autoimmunity, and metabolic diseases (i.e., Type 2 Diabetes).
  • High-Throughput genomic technologies, especially DNA sequencing and SNP genotyping.
  • Anthropological and population genetics, applied to questions of modern human origins and subsequent migrations and local adaptations.

Background:

For the last decade, Mark Seielstad, Ph.D., has been at the forefront of research in human and medical genetics and genetic epidemiology. While a postdoctoral fellow and, later, a faculty member at the Harvard School of Public Health, Dr. Seielstad accomplished a transition from the anthropological and evolutionary genetics of his doctoral training to the related field of medical genetics and genetic epidemiology. This led to a nearly 8 year stint at the Genome Institute of Singapore, where he rose to become the Senior Group Leader and Associate Director of Human Genetics. While there, he built and ran a high-throughput genomics and computational lab centered on the genome-wide genotyping and analysis of SNP variation as it relates to common, primarily immune-related diseases of importance to public health. Now at BSRI in San Francisco, Dr. Seielstad continues his search for human genetic variation that alters susceptibility to and outcomes of infections caused by pathogens of importance to the blood supply. Additional efforts aim to gain insight into the genetic causes of pregnancy and transfusion related alloimmunization. A third research initiative seeks to address a wide variety of other genetic questions of health and disease that are inherently answerable in large cohorts of blood donors and recipients.

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Publications

McGovern DP, Gardet A, Torkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagace C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, D'Amato M, Halfvarson J, Hibberd ML, Lordal M, Padyukov L, Andriulli A, Colombo E, Latiano A, Palmieri O, Bernard EJ, Deslandres C, Hommes DW, de Jong DJ, Stokkers PC, Weersma RK; NIDDK IBD Genetics Consortium, Sharma Y, Silverberg MS, Cho JH, Wu J, Roeder K, Brant SR, Schumm LP, Duerr RH, Dubinsky MC, Glazer NL, Haritunians T, Ippoliti A, Melmed GY, Siscovick DS, Vasiliauskas EA, Targan SR, Annese V, Wijmenga C, Pettersson S, Rotter JI, Xavier RJ, Daly MJ, Rioux JD, Seielstad M. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet. 2010 Apr;42(4):332-7. Epub 2010 Mar 14. PubMed PMID: 20228799.

HUGO Pan-Asian SNP Consortium, Abdulla MA, Ahmed I, Assawamakin A, Bhak J, Brahmachari SK, Calacal GC, Chaurasia A, Chen CH, Chen J, Chen YT, Chu J, Cutiongco-de la Paz EM, De Ungria MC, Delfin FC, Edo J, Fuchareon S, Ghang H, Gojobori T, Han J, Ho SF, Hoh BP, Huang W, Inoko H, Jha P, Jinam TA, Jin L, Jung J, Kangwanpong D, Kampuansai J, Kennedy GC, Khurana P, Kim HL, Kim K, Kim S, Kim WY, Kimm K, Kimura R, Koike T, Kulawonganunchai S, Kumar V, Lai PS, Lee JY, Lee S, Liu ET, Majumder PP, Mandapati KK, Marzuki S, Mitchell W, Mukerji M, Naritomi K, Ngamphiw C, Niikawa N, Nishida N, Oh B, Oh S, Ohashi J, Oka A, Ong R, Padilla CD, Palittapongarnpim P, Perdigon HB, Phipps ME, Png E, Sakaki Y, Salvador JM, Sandraling Y, Scaria V, Seielstad* M, Sidek MR, Sinha A, Srikummool M, Sudoyo H, Sugano S, Suryadi H, Suzuki Y, Tabbada KA, Tan A, Tokunaga K, Tongsima S, Villamor LP, Wang E, Wang Y, Wang H, Wu JY, Xiao H, Xu S, Yang JO, Shugart YY, Yoo HS, Yuan W, Zhao G, Zilfalil BA; Indian Genome Variation Consortium. Mapping human genetic diversity in Asia. Science. 2009 Dec 11;326(5959):1541-5. PubMed PMID: 20007900. *Corresponding Author

Chen J, Zheng H, Bei JX, Sun L, Jia WH, Li T, Zhang F, Seielstad M, Zeng YX, Zhang X, Liu J. Genetic structure of the Han Chinese population revealed by genome-wide SNP variation. Am J Hum Genet. 2009 Dec;85(6):775-85. Epub . PubMed PMID: 19944401; PubMed Central PMCID: PMC2790583.

Davila S, Hibberd ML, Hari Dass R, Wong HE, Sahiratmadja E, Bonnard C, Alisjahbana B, Szeszko JS, Balabanova Y, Drobniewski F, van Crevel R, van de Vosse E, Nejentsev S, Ottenhoff TH, Seielstad M. Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. PLoS Genet. 2008 Oct;4(10):e1000218. Epub 2008 Oct 10. PubMed PMID: 18927625; PubMed Central PMCID: PMC2568981.

Plenge** RM, Seielstad** M, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A, Khalili H, Chandrasekaran A, Davies LR, Li W, Tan AK, Bonnard C, Ong RT, Thalamuthu A, Pettersson S, Liu C, Tian C, Chen WV, Carulli JP, Beckman EM, Altshuler D, Alfredsson L, Criswell LA, Amos CI, Seldin MF, Kastner DL, Klareskog L, Gregersen PK. TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med. 2007 Sep 20;357(12):1199-209. Epub 2007 Sep 5. PubMed PMID: 17804836; PubMed Central PMCID: PMC2636867. **Equal Contributions

Seielstad M, Yuldasheva N, Singh N, Underhill P, Oefner P, Shen P, Wells RS. A novel Y-chromosome variant puts an upper limit on the timing of first entry into the Americas. Am J Hum Genet. 2003 Sep;73(3):700-5. PubMed PMID: 12929085; PubMed Central PMCID: PMC1180698.

Seielstad MT, Minch E, Cavalli-Sforza LL. Genetic evidence for a higher female migration rate in humans. Nat Genet. 1998 Nov;20(3):278-80. PubMed PMID: 9806547.

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