Marcus O. Muench, PhD
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Training / Appointments:
Our research primarily centers on the development of cellular therapies. Current projects focus on the use of pluripotent stem cells for the treatment of blood disorders such as hemoglobinopathies. Our laboratory also has a long-term interest in understanding the development of the liver, including its various cellular elements such as hepatocytes, hematopoietic cells and sinusoidal endothelial cells. We also work closely with many of the investigators at BSRI using in vitro and in vivo models to study various viral and parasitic diseases with the goal of developing methods of preventing infection or new therapies.
Fomin ME, Tai LK, Bárcena A, Muench MO. Coexpression of CD14 and CD326 discriminate hepatic precursors in the human fetal liver. Stem Cells Dev. 2011;20:1247-57. PMID: 20964518. PMCID: PMC3121933.
Bárcena A, Muench MO, Kapidzic M, Gormley M, Goldfien GA, Fisher SJ. Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation. Transfusion. 2011;51 Suppl 4:94S-105S. PMID: 22074633. PMCID: PMC3266842.
Muench MO, Chen JC, Beyer AI, Fomin ME. Cellular therapies supplement: the peritoneum as an ectopic site of hematopoiesis following in utero transplantation. Transfusion. 2011;51 Suppl 4:106S-17S. PMID: 22074621. PMCID: PMC3246414.
Ng TF, Kondov NO, Hayashimoto N, Uchida R, Cha Y, Beyer AI, Wong W, Pesavento PA, Suemizu H, Muench MO, Delwart E. Identification of an astrovirus commonly infecting laboratory mice in the US and Japan. PLoS ONE. 2013;8:e66937. PMID: 23825590. PMCID: PMC3692532.
Fomin ME, Zhou Y, Beyer AI, Publicover J, Baron JL, Muench MO. Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice. PLoS ONE. 2013;8:e77255. PMID: 24167566. PMCID: PMC3805584.
Ye L, Muench MO, Fusaki N, Beyer AI, Wang J, Qi Z, Yu J, Kan YW. Blood cell-derived induced pluripotent stem cells free of reprogramming factors generated by Sendai viral vectors. Stem Cells Transl Med. 2013;2:558-66. PMID: 23847002. PMCID: PMC3726135.